That was a nonnegotiable. Now its not a necessity anymore.
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Protect your medication in extreme cold weather : If you live in or are traveling to places with extreme cold, keep your semaglutide in an inside pocket so your body warmth prevents it from freezing
Rybelsus, the oral semaglutide for type 2 diabetes, tops out at 14 mg daily
Baystate Health
Understanding the difference between lyophilized and liquid peptides explains why liquid formulations are particularly vulnerable to freeze damage