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Yamane et al., 2010)

SGLT2 inhibitors (such as dapagliflozin, empagliflozin, or canagliflozin) represent an alternative class with different mechanisms of action

Histopathological analysis was evaluated by a three-grade system for synovitis (inflammation), cartilage destruction and bone erosion as previously described 54 , five sections for each animal

Tirzepatide may lead to missed periods, irregular cycles, spotting, lighter bleeding, or changes in ovulation due to weight loss, hormone fluctuations, and improved insulin sensitivity

Preclinical studies in rodents show it enhances synaptic connectivity and spatial memory retention with reported potency millions of times greater than BDNF