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& Carlsten, H

Chan et al

Carnitine may be involved because its concentration in tissues declines with age, which deteriorates the mitochondrial membrane

One study found that doses of benzoic acid greater than 0.2g/kg daily or single doses exceeding 0.45g/kg resulted in hyperaethesia, apprehension, and depression 48 to 72 hours post uptake eventually resulting in death in some cats

These chronic attributes are generally associated with selective degeneration of dopaminergic neurons, corollary de-pigmentation of substantia nigra pars compacta (SNpc) and concomitant accumulation of -synuclein in insoluble inclusions called Lewy bodies 2,3