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10.1136/bmjopen-2018-025722 127 ZhangR
Soon, weight loss and improved cardiovascular health were noted in patients taking the breakthrough medication for diabetes, sparking approval of related drugs for obesity
Examples of Drugs with Boxed Warnings Some commonly used medications that carry a Boxed Warning include: Accutane (isotretinoin): severe birth defects during pregnancy Methotrexate: liver toxicity and organ damage Ciprofloxacin: increased risk of tendon rupture Opioids (such as oxycodone, fentanyl): high risk of addiction and overdose Antidepressants (SSRIs, SNRIs): increased risk of suicidal thoughts in young adults Atypical antipsychotics (such as aripiprazole, olanzapine): increased risk of death and cerebrovascular events (such as a stroke) in dementia
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Moreover, melancholic depression is marked by elevated KYN/TRP ratios [48], and KYNA/QA ratios inversely correlate with anhedonia severity [49]
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