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Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs

The Arg-substitution at position 3 in LR3 significantly reduces IGFBP binding, leaving more free IGF-1 available for receptor engagement

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This resulted in a high level of success, as demonstrated in the biosynthesis of truncated lacunalide analogs 353c-j through module deletions and chimeric assembly-line construction