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Taken together, these data demonstrate that mitochondrial function is intrinsically linked to 5FU sensitivity, and that its inhibition may provide an opportunity to increase 5FU efficacy

Unexpectedly, erythronecroptosis is not triggered by tumor necrosis factor- (TNF-) or TNF-related apoptosis-inducing ligand (TRAIL) known as strong inducers of necroptosis in nucleated cells [18]

*: p 0.05

This phenomenon is indeed elusive, but it is speculated that there may be other antioxidant pathways that inhibit this process

10.1517/17425250903427980 Expert Opin

In this section, we explore potential therapeutic strategies reported to date, discussing their practical applications and limitations in OA, and then offer prospects for future investigations