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Besides, the protective effect of berberine resisting MTPT-induced toxicity may be related to the enhancement of autophagy by berberine through AMPK-dependent pathways ( The study found that berberine alleviated the severity of symptoms in the multiple sclerosis mouse model, and in primary astrocyte culture, berberine inhibited the increase in sphingosine kinase-1 (SphK1), and Sphingosine-1-phosphate (S1P) induced by lipopolysaccharide
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