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One benefit of studying cells in a dish, rather than studying actual people, is that you can limit variables, Goniewicz says

The most commonly affected areas include around the mouth, the genitals, and the buttocks

Based on 14 reviews of intervention studies (seven high-quality), the researchers found that of 21 meta-analytic comparisons of nicotine EC versus other interventions, all reported point estimates favoring nicotine EC for smoking cessation, with relative risks or odds ratios ranging from 1.17 to 1.67 versus nicotine replacement therapy and 1.46 to 2.09 versus non-nicotine EC

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