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Chronic oxidative stress in synovial T-lymphocytes of patients with RA results from intracellular ROS production (mainly H 2 O 2 ) (194), and ROS may be involved in destructive pathological events of RA

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In contrast, studies have demonstrated that the inhibition of glutamine metabolism in cancer cells using the DON precursor drug DRP-104 results in an augmentation of the number of NK and NK T-cells within the immune microenvironment, thereby enhancing anti-tumor immunity [121]

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