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Bonaccorsi di Patti, M

L-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans

Clinical studies have demonstrated its efficacy in patients with recurrent metastatic nasopharyngeal carcinoma

One of the significant challenges can be proving clinical effectiveness in humans by relying on in vitro data and animal model data, which may not always accurately mirror human disease progression and pharmacological response mechanisms

As mentioned before, Pycnogenol was shown to have potent antioxidant efficacy and protects lipids, DNA and proteins from oxidation within the body in addition to its ability to increase blood antioxidant capacity ( Another property of Pycnogenol explaining its effect of increased performance is the improved tissue perfusion by enhancing microcirculation ( 3 Discussion Pycnogenol s unique composition of bioactive substances with diverse biological targets explains its efficacy on a broad range of human health conditions

KEGG: new perspectives on genomes, pathways, diseases and drugs