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Treating obesity can be complicated so it is best to work with a knowledgeable health care professional who is dedicated to working with you over the long term

Avoid high-fat and high-sugar meals, which can worsen GI side effects

A 2025 meta-analysis has also reported a similar trend after analyzing clinical trials and observational studies: tirzepatide produced about 4% greater weight loss than semaglutide [8]

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From a practical standpoint, people should be informed of the characteristic symptoms of acute pancreatitis, and treatment with GLP-1 RA should be discontinued if pancreatitis is suspected and not restarted if confirmed